From Atlasphere member Noah Rusnock:
I am not sure how much the Atlasphere community is involved with video games, but in the next few months a highly-anticipated, main stream video game with an Objectivist base will hit the market. The game is called BioShock and you can read about it here, here, and here.
UPDATE: For more about the game, check out the hands-on preview at Shacknews.